A drug dealer collapses during a sale, but refuses to reveal personal information to the team because it might incriminate him. Meanwhile, Foreman’s teammates conspire to play a practical joke on him, while House and Wilson both aim their sights on an attractive new neighbor, Nora.

The team treats a controversial African politician named Dibala (James Earl Jones) who has fallen ill while coming to America to give a speech at the United Nations. Meanwhile, Wilson tries to make amends with a feuding neighbor.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son’s medical [...]

Cameron pushes the team to treat a man whose father, grandfather and great-grandfather have all died of a sudden heart attack before the age of 40, but House is reluctant to take the case without distinctive symptoms. Meanwhile, Chase is haunted by his actions in the Dibala case.

After a wild night out, a teenage girl (guest star Anna Attanasio) is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. [...]

After House’s medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick (guest star Troy Garity), an adult film star admitted to Princeton Plainsboro for pulsating eye pain. Meanwhile, Cuddy is reminded that Princeton Plainsboro is not conducive to healthy personal relationships.

On the eve of Thanksgiving, House and the team take on the case of James Sidas (guest star Esteban Powell), an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled [...]

Wilson insists on treating the case of a friend and former patient, Tucker, who is suffering from paralysis of his right arm. However, he soon discovers that he can’t separate his feelings from his professional attitude. Meanwhile, Cuddy tries to buy a new house.